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Cobb Laboratory Publications

Mojumdar, A*, Mair, N*, Adams, A, and Cobb, J.A. (2022). Changes in DNA double-strand break repair pathway usage coincidences with increased mutation rates during replicative aging in budding yeast. J Mol Biol. 434, 167798, doi:10.1016/j.jmb.2022.167798. (*co-first authorship)


Mojumdar, A, Adams, A, and Cobb, J.A. (2022). Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice. DNA Repair. 115:103332, doi:10.1016/j.dnarep.2022.103332.


Mojumdar, A, Adams, A, and Cobb, J.A. (2022). Nej1 interacts with Sae2 at DNA double-stranded breaks to inhibit DNA resection. J Biol Chem. 298(6):101937, doi:10.1016/j.jbc.2022.101937


Moradi-Fard, S, Mojumdar, A, Chan, M, Harkness, T, and Cobb, J.A. (2021). A Fob1 independent role for the Smc5/6 complex in the rDNA that modulates lifespan. Aging Cell. 20(6):e13373, doi: 10.1111/acel.13373.


Forey, R, Barthe, A, Tittel-Elmer, M, Wery, M, Barrault, M, Ducrot, C, Seeber, A, Krietenstein, N, Szachnowski, U, Aeillo, U, Skryzpczak, M, Ginalski, Cobb, J.A., Libri, D, Rando, O, Soutourina, J, Dubrana, K, Gasser, SM, Morillon, A, Pasero, P, Lengronne, A, and Poli, J. (2021). A role for the Mre11-Rad50-Xrs2 complex in gene expression and chromosome organization. Molecular Cell. 81(1), 1-15. doi: 10.1016/j.molcel.2020.11.010.


Stanley, FKT, Berger, DN, Pearson, D, Danforth, JM, Morrison, H, Johnston, JE, Warnock, TS, Brenner, DR, Chan, JA, Pierce, G, Cobb, J.A., Ploquin, NP, Goodarzi, AA. (2020). A high-throughput alpha particle irradiation system for monitoring DNA damage repair, genome instability and screening in human cell and yeast model systems. Nucleic Acids Res. 48(19), 1-16.  doi: 10.1093/nar/gkaa782.


Hohl, M., Mojumdar, A., Hailemariam, S., Kuryavyi, V., Ghisays, F., Sorenson, K., Chang, M., Taylor, B.S., Patel, D.J., Burgers, P.M., Cobb, J.A., and Petrini, J.H.J (2020) Modeling Cancer Genomic Data in Yeast Reveals Selection Against ATM Function During Tumorigenesis. PLOS Genetics. doi: 10.1371/journal.pgen.1008422.


Mojumdar, A., Sorenson, K., Hohl, M., Toulouze, M., Lees-Miller, S.P., Dubrana, K.,  Petrini, J., and Cobb, J.A. (2019) Nej1 interacts with Mre11 to regulate end-tethering and Dna2 binding at DNA double-strand breaks. Cell Reports. 28(6):1564-1573.e3. doi: 10.1016/j.celrep.2019.07.018.


Sorenson, K., Mahaney, B., Lees-Miller, S.P. and Cobb, J.A. (2017) The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 at DNA double strand breaks. J Biol Chem. 292(35):14576-14586.   doi: 10.1074/jbc.M117.796011.


Moradi-Fard, S., Sarthi, .J., Tittel-Elmer, M.V.,  Lalonde, M., Cusanelli, E., Chartrand, P., and Cobb, J.A. (2016) Smc5/6 is telomere-associated complex that regulates Sir4 binding and TPE.

PLoS Genetics  12 (8): e1006268.


Bustard, D., Ball, L.G., and Cobb, J.A. (2016) Non-SMC Element 5 (NSE5) of the Smc5/6 complex interacts with SUMO pathway components.  Biology Open 5 (6), 777-785.


Horigome, C.*, Bustard, D.*, Marcomini, I., Delgoshaie, N., Tsai-Pflugfelder, M., Cobb, J.A., and Gasser, S.M. (2016) PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes and Development, 30 (8), 931-945. 

(*co-first authorship)


Renaud-Young, M., Lloyd, D.C., Chatfield-Reed, K., George, I., Chua, G., and Cobb, J.A. (2015) The NuA4 complex promotes Translesion Synthesis (TLS)-mediated DNA damage tolerance. GENETICS, 199 (4), 1065-1076.


Ball, L.G., Hanna, M.D., Lambrecht, A.D., Mitchell, B.A., Ziola, B., Cobb, J.A., and Xiao, W. (2014) The Mre11-Rad50-Xrs2 complex is required for yeast DNA postreplication repair. PLOS One, 9 (10), e109292.


Mahaney, B., Lees-Miller, S.P. and Cobb, J.A. (2014) The C-terminus of Nej1 is critical for nuclear localization and non-homologous end joining. DNA Repair 14, 9-16.  


Tittel-Elmer, M.V., Lengronne, A., Davidson, M., Bacal, J., Francois, P., Hohl, M., Petrini, J., Pasero, P., and Cobb, J.A. (2012) Cohesin association to replication sites depends on Rad50 and promotes fork restart. Molecular Cell, 48 (1), 98-108.  (Faculty of 1000) 


Bustard, D., Menolfi, D., Jeppsson, K., Ball, L.G., Dewey, S.C., Shirahige, K., Sjogren, C., Branzei, D., and Cobb, J.A. (2012) During replication stress Non-Smc-Element 5 is required for Smc5/6 complex functionality at stalled forks. J Biol Chem, 287 (14), 11374-11383.


Ball, L.G., Zhang, K., Cobb, J.A., Boone, C. and Xiao, W. (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol. Microbiol 73, 89-102.


Tittel-Elmer, M.V., Alabert, C., Pasero, P., and Cobb, J.A. (2009) The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. EMBO J, 28,1142-56. (recommended by the Faculty of 1000)

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